Name: TOPOGRAPH Precison Oncology Compendium
License: https://creativecommons.org/licenses/by-nc-sa/4.0/

A
ABL1

BCR-ABL1 Fusion, BCR-ABL1 Fusion and T315I, BCR-ABL1 fusion AND T315I AND E355G, NUP214-ABL1 fusion, G250H, Q252H, Y253H, E255K, E255V, V299L, T315A, T315I, F317C, F317I, F317L, F317V, A337V, F359C, F359I, F359V, E459K, P465S, F486S
AKT1

LAMTOR1-AKT1 fusion, Oncogenic mutation, Oncogenic mutations, E17K
AKT2

Oncogenic mutations
AKT3

Oncogenic mutations
ALK

CAD-ALK fusion, EML4-ALK Fusion, Fusion, Fusion AND Amplification, Fusions, NPM-ALK fusion, RANBP2-ALK Fusion, SPECC1L-ALK fusion, STRN-ALK fusion, VCL-ALK fusion, VKORC1L1-ALK fusion, Oncogenic mutation, Oncogenic mutations, Exon 2-17 deletion, Exon 2–3 deletion, Amplification, A348D, F856S, L1122V, G1128A, E1129V, I1151ins, T1151, T1151K, T1151M, T1151R, T1151_L1152insT, T1151ins, T1151insT, L1152P, L1152R, L1152V, C1156T, C1156Y, C1156Y and G1202R, D1160H, I1171, I1171N, I1171N and D1203N, I1171N and L1198F, I1171S, I1171T, I1171ins, F1174, F1174C, F1174L, F1174S, F1174V, V1180L, R1192P, L1196M, L1196M and G1202R, L1196M and L1198F, L1196Q, F1197M, L1198F, L1198F and C1156Y, L1198F and G1202R, L1198P, G1202R, G1202R and F1174L, G1202R and G1269A, G1202R and L1196M, G1202R and L1198F, G1202R and T1151M, G1202del, D1203E, D1203N, D1203N and E1210K, S1206C, S1206F, S1206R, S1206Y, E1210K, E1210K and D1203N, E1210K and S1206C, F1245C, F1245L, F1245V, F1245Y, G1269A, G1269S, S1269S, R1275Q, D1276_R1279, Y1278S, E1408V
APC

Oncogenic mutations, Loss-of-function mutations
APC+PIK3CA

APC:Oncogenic mutations AND PIK3CA:Oncogenic mutations
AR

Oncogenic mutations, Amplification, Amplifications, L702H, L702H and H875Y, L702H and T878A, L702H and W742C and T878A, V716M, V731M, W742C, W742C and T878A, W742L, H875Q, H875Q and T919S, H875Y, H875Y and T878A, F877L, F877L and T878A, T878A, T878A and D891H, T878A and S889G, T878S, D880E, L882I, S889G, D891H, E894K, M896T, M896V, E898G, T919S, AR-FL, AR-V7, Alteration, Ligand-binding domain mutation, Overexpression, Protein expression, Wildtype
AR+ESR1 (ER)

AR:Protein expression and ESR1:Protein expression
ARAF

Oncogenic mutations, S214C, P216A, K336M, K336M and G387D, R362H and G387D, G377R, G387D, G387R, G387S, P462L, Overexpression
ARID1A

Oncogenic mutation, Oncogenic mutations, Oncogenic mutations AND Loss of protein expression, Oncogenic mutations AND NOT Loss of protein expression, Loss-of-function mutations, Truncating mutations
ARID1B

Oncogenic mutations
ARID2

Loss of protein expression, Loss-of-function mutations
ATM

Oncogenic mutation, Oncogenic mutations, Oncogenic mutations (germline), deletion, S1905Ifs*25, Loss of protein expression, Loss-of-function mutations, Loss-of-protein expression, Protein expression, Truncating mutations
ATM+TP53

ATM:Oncogenic mutations and NOT TP53:Oncogenic mutations
ATR

Oncogenic mutation, Oncogenic mutations, Overexpression
ATRX

Oncogenic mutation, Oncogenic mutations, Loss-of-function mutations
AURKA

Amplification

B
B2M

deletion, Loss of protein expression, Loss-of-function mutations
BAP1

Oncogenic mutations, deletion, Loss of protein expression, Loss-of-function mutations
BARD1

Oncogenic mutations, Oncogenic mutations (germline), Loss-of-function mutations
BCL2

Amplification, G101V, D103Y, A113G, Overexpression
BCL2L1

Amplification
BCL2L11

deletion
BCL6

Protein expression
BRAF

AGAP3-BRAF fusion, AGK-BRAF fusion, AKAP9-BRAF fusion, BCAP29-BRAF fusion, CUL1-BRAF fusion, FKBP15-BRAF fusion, Fusion, Fusions, KIAA1549-BRAF fusion, LUC7L2-BRAF fusion, MBNL2-BRAF fusion, PJA2-BRAF fusion, SKAP2-BRAF fusion, SND1-BRAF fusion, TARDBP-BRAF fusion, ZC3HAV1-BRAF fusion, Class I mutation, Class I mutations, Class II mutation, Class II mutations, Class III mutation, Class III mutations, Oncogenic mutation, Oncogenic mutations, Oncogenic mutations AND NOT V600, Exon 12 deletion, Amplification, V600E and Amplification, V226M, F247L, D287, D287H, I326V, E375D, A400V, V459, V459L, G464E, G464V, G466, G466A, G466E, G466V, S467, S467L, G469A, G469R, G469V, T470R, L485F, L485_P490del, L485_P490delinsF, L485_P490delinsY, L485delinsFS, N486_P490del, N486_T491del, V487_P492>, V487_P492del, V487_P492delinsA, L505H, Y519F, Q524L, L525R, R558Q, G569R, N581, N581I, N581S, N581T, N581Y, D594, D594A, D594G, D594H, D594N, F595, F595L, G596, G596C, G596D, G596R, L597, L597Q, L597R, L597V, A598_T599insV, T599_V600TinsT, T599_V600insT, V600, V600E, V600E and L514V, V600K, V600M, V600R, K601, K601E, K601N, K601T, I617V, A, BRAF-CREB3L2 rearrangement
BRAF+EGFR

EGFR:exon 19 deletion and BRAF:V600E
BRAF+KRAS

BRAF:V600E AND KRAS:Oncogenic mutations, BRAF:V600E AND KRAS:A146, BRAF:V600E AND KRAS:G12, BRAF:V600E AND KRAS:G12D, BRAF:V600E AND KRAS:G13, BRAF:V600E AND KRAS:K117, BRAF:V600E AND KRAS:Q61, BRAF:V600E AND KRAS:Q61R
BRAF+MAP2K1

BRAF:V600E AND MAP2K1:Oncogenic mutations, BRAF:V600E AND MAP2K1:F53, BRAF:V600E AND MAP2K1:K57, BRAF:V600E AND MAP2K1:K57N
BRAF+MET

Amplification, BRAF:V600E AND MET:amplification
BRAF+NRAS

BRAF:V600E AND NRAS:Oncogenic mutations, BRAF:V600E AND NRAS:G12, BRAF:V600E AND NRAS:G13, BRAF:V600E AND NRAS:Q61, BRAF:V600E AND NRAS:Q61R
BRAF+PTEN

BRAF:V600E AND PTEN:Oncogenic mutations
BRCA1

Oncogenic mutations, Oncogenic mutations (germline), Oncogenic mutations AND NOT Oncogenic mutations (germline), M1I, M1V, C61G, C64Y, R71G, R71K, S1253fs*10, R1495M, E1559K, D1692H, D1692N, R1699W, A1708E, G1788V, 9435_9436delGT, Loss of protein expression, Loss-of-function mutations, Promoter methylation, Reversion mutations
BRCA1+BRCA2

NOT BRCA1:Oncogenic mutations (germline) and NOT BRCA2:Oncogenic mutations (germline), NOT BRCA1:Oncogenic mutations and NOT BRCA2:Oncogenic mutations
BRCA1+ERBB2 (HER2)

BRCA1:Oncogenic mutation and NOT ERBB2:Overexpression and NOT ERBB2:Amplification
BRCA2

Oncogenic mutation, Oncogenic mutations, Oncogenic mutations (germline), Oncogenic mutations AND NOT Oncogenic mutations (germline), Deletions, M1I, M1R, V159M, V211I, V211L, R2336H, R2336P, Loss-of-function mutations, Promoter methylation, Reversion mutations
BRCA2+PTEN

BRCA2:deletion and PTEN:deletion
BRD3

BRD3-NUTM1 fusion
BRD4

BRD4-NUTM1 fusion, Fusion, Oncogenic mutations
BRD7

Loss-of-function mutations
BRIP1

Oncogenic mutation, Oncogenic mutations, Q554Hfs*35, Loss-of-function mutations

C
CALB1

High mRNA expression
CAMTA1

TAZ-CAMTA1 fusion
CBL

Y371H, C384R
CCL11

Serum level high
CCND1

Amplification, Overexpression
CCND2

Amplification
CCND3

Amplification
CCNE1

Amplification, Overexpression, mRNA expression
CCR4

Protein expression
CD123

Overexpression
CD19

Overexpression, Protein expression
CD20

Protein expression
CD274 (PD-L1)

Amplification, Loss of protein expression, Protein expression
CD274+EGFR+ALK

CD274:Protein expression and NOT EGFR:Oncogenic mutations and NOT ALK:fusion
CD276 (B7-H3)

Protein expression
CD33

Protein expression
CD38

Overexpression
CD79B

Protein expression
CD8

High
CDH1

Loss-of-function mutations
CDH6

Protein expression
CDK12

Oncogenic mutation, Oncogenic mutations, Kinase domain mutations, Loss of protein expression, Loss-of-function mutations, Protein expression, Rearrangement, Truncating mutations
CDK4

Oncogenic mutations, Amplification, Amplification and NOT overexpression, Overexpression
CDK6

Oncogenic mutations, Amplification, Overexpression
CDKN2A

Oncogenic mutation, Oncogenic mutations, Deletions, deletion, Loss of protein expression, Loss-of-function mutations, Truncating mutations
CDKN2A+MTAP

CDKN2A:deletion and MTAP:deletion
CEACAM5

Overexpression, Protein expression
CHEK1

Oncogenic mutations, Loss-of-function mutations, Overexpression
CHEK2

Oncogenic mutation, Oncogenic mutations
CLDN18

Low protein expression, Overexpression, Protein expression
CLDN18+ERBB2 (HER2)

CLDN18:Protein expression AND NOT ERBB2:Amplification, CLDN18:Protein expression AND NOT ERBB2:Overexpression
CLDN6

Protein expression
CRKL

Amplification, Overexpression
CSF1

Fusion, Overexpression, Rearrangement
CTAG1B

Overexpression, Protein expression
CTNNB1

Oncogenic mutations, T41A, S45F, Gain-of-function mutations
CTNNB1+KIT

CTNNB1:S33C and KIT:L576P
CXCL13

Overexpression
CXCR4

S338X
Chromosome

3p25.3 copy number gain
Consensus molecular subtype

CMS2, CMS3, CMS4

D
DAXX

Oncogenic mutation, Overexpression
DHFR

Amplification
DLK1

Protein expression
DLL3

High expression, Protein expression
DNMT3A

Oncogenic mutations, Deletions, Loss-of-function mutations, Truncating mutations

E
EGFR

EGFR-PURB fusion, EGFR-RAD51 fusion, EGFR-SEPT14 Fusion, KIF5B-EGFR fusion, Amplification AND NOT Oncogenic mutations, Amplification and NOT Oncogenic mutation, Oncogenic mutation, Oncogenic mutation and NOT Exon 19 deletion and NOT L858R, Oncogenic mutations, Exon 18 deletion, Exon 18 mutation, Amplification and Exon 19 deletion, EGFR:exon 19 deletion and BRAF:V600E, Exon 19 deletion, Exon 19 deletion and C797S, Exon 19 deletion and G724S, Exon 19 deletion and G796S, Exon 19 deletion and L718Q, Exon 19 deletion and L718V, Exon 19 deletion and L792F, Exon 19 deletion and L792H, Exon 19 deletion and T790M, Exon 19 deletion and T790M and C797S, Exon 19 deletion and T790M and G724S, Exon 19 deletion and T790M and L718V, Exon 19 deletion and T790M and L792H, Exon 19 deletion and T854I, Exon 19 deletion and amplification, Exon 19 deletions, Exon 19 indels, Exon 19 insertion, Exon 20 insertion, Exon 20 insertion and T790M and C797S, Exon 20 insertion except A763_Y764insFQEA, Exon 20 insertion mutations, Exon 20 insertions, Exon 20 mutation, Exon 21 mutation, Exon 21 mutation and amplification, Amplification, Amplification AND G598V, Amplification and L858R, L858R and amplification, G63R, E114K, R165Q, R222C, T263P, A289D, A289V, R451C, S464L, G465R, K467T, I491M, S492R, P596L, G598V, V659E, K708R, E709A, E709A and G719S, E709K, E709K and G719S, E709K and L858R, E709_T710delinsD, L718Q, L718Q and T790M, L718V, G719, G719A, G719A and L861Q, G719A and R776C, G719A and T790M, G719S, G719S and E709K, G719S and R776H, G719S and T790M, G719Y, S720P, G724S, G724S and R776H, G724S and T790M, T725M, I740_K745dupIPVAIK, I740dupIPVAK, L747P, L747S, L747_A750delinsP, L747_K754delInsATSPE, L747_P753delinsS, L747_T751del and D837T, T751_I759delinsS, S752_I759del, K754E, K757R, D761N, D761Y, A763_Y764insFQEA, A763_Y764insLQEA, A763insFQEA, A767_V769dup, A767insASV, S768I, S768I and T790M, S768I and V769L, S768I and V774M, S768_D770dup, S768dupSVD, S768dupSVD and V769M, V769L, V769_D770insASV, V769_D770insGG, V769insASV, D770_N771insG, D770_N771insGD, D770_N771insGL, D770_N771insSVD, D770delinsDV, D770delinsGY, D770insG, D770insNPG, D770insSVD, D770insY, N771_H773dup, N771_P772insH, N771_P772insSVDN, N771delinsKH, N771dupN, N771dupN and G724S, N771insH, P772_H773insGNP, P772_H773insPNP, P772dupDNP, H773L and V774M, H773Y, H773_V774insAH, H773_V774insH, H773_V774insNPH, H773_V774insPHPH, H773insH, H773insNPH, V774M, V774_C775insHV, R776C, R776H, F784F, S784F, T790M, T790M and C797S and T790M-C797S trans-allelic conformation, T790M and G796R, T790M and L792H, L792, L792H, C797G, C797S, C797S and T790M, K806E, S811F, N826Y, L833F, L833V, L833V and H835L, H835L, N842S, V843I, T847I, V851I, T854A, L858R, L858R and A871E, L858R and C797G, L858R and C797S, L858R and G724S, L858R and G873E, L858R and L718Q, L858R and L718V, L858R and L792F, L858R and L792H, L858R and S784F, L858R and T790M, L858R and T790M and C797S, L858R and T790M and L718Q, L858R and T790M and L718V, L858R and T790M and L792H, L858R and T790M and V843I, L858R and V834L, L861Q, L861R, Kinase domain duplication, Kinase domain duplication AND T790M, Kinase domain duplication AND T790M AND C797S, Overexpression, Protein expression, activating mutations, ectodomain mutation, vIII, vIII AND D247Y
EGFR+ALK

EGFR:Oncogenic mutations and ALK:fusion
EGFR+BRAF

EGFR:Oncogenic mutations and BRAF:V600E
EGFR+CD274

CD274:Protein expression and EGFR:Oncogenic mutations
EGFR+EGFR

Amplification and Exon 19 deletion, C797S and Exon 19 deletion, E709K and Exon 19 deletion, G724S and Exon 19 deletion, G796S and Exon 19 deletion, L718 and Exon 19 deletion, L792H and Exon 19 deletion, Amplification and L858R, E709K and L858R, L718 and L858R, G724S and L858R, L792H and L858R, G796S and L858R, C797S and L858R, EGFR:T790M and EGFR:C797S and EGFR:T790M-C797S cis-allelic conformation
EGFR+ERBB2 (HER2)

EGFR:Oncogenic mutations and ERBB2:amplification, EGFR:Exon 19 deletion and ERBB2:Amplification
EGFR+ERBB3

EGFR:Protein expression AND ERBB3:Protein expression
EGFR+ERRFI1

EGFR:low expression AND ERRFI1:Oncogenic mutations, EGFR:overexpression AND ERRFI1:Oncogenic mutations
EGFR+MET

EGFR:Oncogenic mutation AND MET:amplification AND MET:D1228, EGFR:Oncogenic mutation AND MET:amplification AND MET:D1230, EGFR:Oncogenic mutations and MET:amplification, EGFR:Oncogenic mutations and MET:amplification and NOT EGFR:T790M, MET:Alteration and EGFR:Oncogenic mutations, MET:overexpression AND NOT EGFR:oncogenic mutation, EGFR:L858R and MET:exon 14 skipping mutation, EGFR:Exon 19 deletion and MET:amplification, EGFR:Exon 19 deletion and MET:exon 14 skipping mutation, MET:amplification and EGFR:exon 19 deletion, EGFR:L858R and MET:amplification, EGFR:T790M and MET:amplification, MET:amplification and EGFR:L858R
EGFR+MET+ALK

EGFR:Oncogenic mutation AND MET:amplification AND EML4-ALK fusion
EGFR+MET+BRAF

EGFR:Oncogenic mutation AND MET:amplification AND BRAF:Oncogenic mutation
EGFR+MET+KRAS

EGFR:Oncogenic mutation AND MET:amplification AND KRAS:Oncogenic mutation
EGFR+RB1

EGFR:Oncogenic mutations and RB1:Oncogenic mutations
EGFR+RBM10

EGFR:Oncogenic mutations and RBM10:Loss-of-function mutations
EGFR+RET

EGFR:Exon 19 deletion and EGFR:T790M and RET:ANK3-RET fusion, EGFR:Oncogenic mutations and RET:fusion
EGFR+ROS1

EGFR:Oncogenic mutations and ROS1:fusion, GOPC-ROS1 Fusion
EGFR+TP53

EGFR:Oncogenic mutations and TP53:Oncogenic mutations
EIF1AX

G6_splice, G8V, G9, K10N, R13, G15D, A113_splice, N-terminal tail mutation
EIF1AX+NRAS

EIF1AX:A113splice and NRAS:Oncogenic mutations, EIF1AX:Oncogenic mutations and NRAS:Oncogenic mutations
EIF4EBP1

Protein expression
EMSY

Amplification, Overexpression
EPAS1

Oncogenic mutations (germline), A530E (germline)
EPHA7

Oncogenic mutations
ERBB2 (HER2)

ERBB2-GRB7 fusion, Fusions, MDK-ERBB2 fusion, ZNF207-ERBB2 fusion, ERBB2:Oncogenic mutations and NOT ERBB2:amplification, Oncogenic mutation, Oncogenic mutations, Overexpression AND NOT Oncogenic mutations, Protein expression AND NOT Oncogenic mutations, Exon 16 skipping mutation, Exon 20 insertion, Exon 20 insertion except G778ins, Exon 20 insertion mutation, Exon 20 mutation, Exon 21 mutation, Amplification, Amplification and A775_G776insTVMA, Amplification and D769Y, Amplification and L313I, Amplification and L755S, Amplification and NOT overexpression, Amplification and R456C, Amplification and S310F, Amplification and V777L, ERBB2:amplification, ERBB2:amplification and KRAS:G12D, Low protein expression and NOT Amplification, NOT Amplification and NOT Overexpression, Protein expression AND Amplification, Protein expression AND Amplification AND NOT Overexpression, Protein expression NOT amplification, Protein expression and NOT Amplification, Q57R, p95 expression, S113F, R188C, S250C, E265K, D277H and S310F, D277Y, G309A, G309E, S310, S310A, S310F, S310Y, E321G, S335C, E395K, L403V, R487W, P489L, S653C, V659D, V659E, G660D, G660D and S310F, G660R, Q678Q, R678Q, D679H, V697L, Q709, D742N, K753E, L755A, L755F, L755M, L755P, L755S, L755_759del, L755_T759del, G766V, I767M, I767N, A769H, D769H, D769N, D769Y, V773M, M774dup, A775_G776insTVMA, A775_G776insYVMA (Y772_A775dup), A775_Y776insYVMA, A775_Y776insYVMA (Y772_A775dup), G776, G776C, G776R, G776S, G776V, G776_V777delinsCVC, G776_V777delinsCVCS310Y, G776_V777delinsLC, G776_V777delinsVV, G776delinsLC, G776delinsVC, G776delinsVG, G776ins, V777L, V777M, V777_G778insGC, V777_G778insV, G778_S779insG, G778_S779insLPS, G778ins, G778insCPG, S779_P780insVGS, S779ins, P780_Y781insGSP (G778_P780dup), P780ins, L785F, L786V, T798I, T798M, C805S, G815R, L841V, V842I, N857S, T862A, L869R, L869R and T798I, R896C, D962N, L1157R, P1199S, P1199T, Alteration, Extracellular domain mutation, Extracellular domain mutations, Intracellular domain, Juxtamembrane domain mutation, Kinase domain mutation, Low protein expression, Low-protein expression, No protein expression, Overexpression, Protein expression, Transmembrane domain, Transmembrane domain mutation, Tyrosine kinase domain mutation, Tyrosine kinase domain mutations, transmembrane domain mutations
ERBB2 (HER2)+CD274

CD274:Protein expression and NOT ERBB2:Amplification and NOT ERBB2:Overexpression
ERBB2 (HER2)+ERBB3

ERBB2:Oncogenic mutation and ERBB3:E928G, ERBB2:L755S and ERBB3:E928G, ERBB2:L869R and ERBB3:E928G, ERBB2:S310F and ERBB3:E928G, ERBB2:V777L and ERBB3:E928G
ERBB2 (HER2)+ESR1 (ER)

ESR1:Protein expression and NOT ERBB2:amplification and NOT ERBB2:overexpression
ERBB2 (HER2)+KRAS

ERBB2:Amplification AND KRAS:Oncogenic mutations, ERBB2:Amplification and ERBB2:Protein expression and NOT KRAS:Oncogenic mutations and NOT BRAF:V600E, ERBB2:Oncogenic mutations AND KRAS:Oncogenic mutations, ERBB2:Overexpression AND KRAS:Oncogenic mutation, ERBB2:Overexpression AND KRAS:Oncogenic mutations, ERBB2:Overexpression and NOT KRAS:Oncogenic mutations and NOT BRAF:V600E, ERBB2:Protein expression AND KRAS:Oncogenic mutation, ERBB2:amplification and KRAS:G12, ERBB2:amplification and KRAS:G12D
ERBB2 (HER2)+PTEN

ERBB2:Oncogenic mutations and PTEN:Deletion, ERBB2:Oncogenic mutations and PTEN:Loss of protein expression, ERBB2:Oncogenic mutations and PTEN:Loss-of-function mutations, ERBB2:Oncogenic mutations and PTEN:Oncogenic mutations
ERBB3

Oncogenic mutation, Oncogenic mutations, Amplification, F94L, R103G, V104L, V104M, A232V, G248R, P262H, G284R, D297Y, T355A, T355I, Y789fs, Q809R, S846I, S864I, Q865H, E928G, E1261A, Extracellular domain mutations, Low protein expression, Overexpression, Protein expression, Truncating mutations
ERBB4

Oncogenic mutations, R687K, E715K
ERCC1

Oncogenic mutations, Loss of protein expression
ERCC2

Oncogenic mutations
ERRFI1

deletion, E384X, Loss-of-function mutations
ESR1 (ER)

ESR1-ARNT2 fusion, ESR1-PCDH11X fusion, ESR1-SOX9 fusion, ESR1-YAP1 fusion, Fusion, Oncogenic mutations, D351Y, E380, E380Q, E380Q and F404L, V392I, F404I, F404L, F404V, V422del, S463P, M528I, V534E, P535H, L536, L536H, L536P, L536Q, L536R, Y537, Y537C, Y537D, Y537N, Y537S, D538, D538G, D538G and F404L, Protein expression
ESR1 (ER)+CCNE1

ESR1:Protein expression and CCNE1:Amplification
ESR1 (ER)+ERBB2 (HER2)

ESR1:Protein expression and ESR1:oncogenic mutations and NOT ERBB2:amplification and NOT ERBB2:overexpression, ESR1:Protein expression and ERBB2:Low protein expression and NOT ERBB2:amplification, ESR1:Protein expression and ERBB2:Protein expression and NOT ERBB2:amplification, ESR1:Protein expression and NOT ERBB2:amplification and NOT ERBB2:overexpression, ESR1:D538, ESR1:Protein expression and ERBB2:Ultra-low protein expression, ESR1:Y537, NOT ESR1:protein expression and NOT ERBB2:amplified, NOT ESR1:protein expression and NOT ERBB2:overexpression
ESR1 (ER)+ERBB2 (HER2)+PIK3CA

ESR1:Protein expression and NOT ERBB2:amplification and NOT ERBB2:overexpression and PIK3CA:Oncogenic mutations
ESR1 (ER)+MDM2

ESR1:Protein expression AND MDM2:Amplification
ESR1 (ER)+PIK3CA

ESR1:protein expression and PIK3CA:oncogenic mutation
ESR1 (ER)+TP53

ESR1:Protein expression AND TP53:Oncogenic mutations
EZH2

Oncogenic mutations, Y641C, Y641F, Y641H, Y641N, Y641S, Y646, Y646C, Y646F, Y646H, Y646N, Y646S, Y666N, A677G, A682G, A682V, A687V, A692V

F
F3

Protein expression
FAM175A

Loss-of-function mutations
FANCA

S1088F, Loss-of-function mutations
FANCC

Oncogenic mutations, Loss of protein expression
FANCD2

Oncogenic mutations, Oncogenic mutations (germline), Loss-of-function mutations
FANCG

Oncogenic mutations
FANCI

Oncogenic mutations
FANCL

Oncogenic mutations
FANCM

Oncogenic mutations
FAT1

Loss-of-function mutations
FBXW7

Oncogenic mutation, Oncogenic mutations, deletion, L403fs*34, R465C, R479Q, R505, R505C, R505H, G579W, R658Q, S668fs*39, Loss-of-function mutations
FGF19

Amplification, Overexpression
FGFR1

FGFR1-PLAG1 fusion, FGFR1-TACC1 fusion, Fusion, Fusions, Oncogenic mutations, Oncogenic mutations and NOT V561, Amplification, N546D, N546K, V559L, V559M, V561M, M563T, N564K, K656E, Alteration, High mRNA expression, Overexpression, Rearrangement
FGFR2

BCR-FGFR2 fusion AND N549K (N550K), BCR-FGFR2 fusion AND V565F, BCR-FGFR2 fusion AND V565I, FGFR1-WDHD1 fusion, FGFR2-ACLY fusion, FGFR2-ACOT11 fusion, FGFR2-AFF4 fusion, FGFR2-AHCYL1 fusion, FGFR2-ARHGAP22 fusion, FGFR2-ARHGAP24 fusion, FGFR2-ATAD2 fusion, FGFR2-ATE1 fusion, FGFR2-ATF2 fusion, FGFR2-BICC1 fusion, FGFR2-BICD1 fusion, FGFR2-CASP7 fusion, FGFR2-CCDC158 fusion, FGFR2-CCDC170 fusion, FGFR2-CCDC6 fusion, FGFR2-CEP128 fusion, FGFR2-CLIP1 fusion, FGFR2-COL16A1 fusion, FGFR2-CROCC fusion, FGFR2-CTNNA3 fusion, FGFR2-DBP fusion, FGFR2-DNAJC12 fusion, FGFR2-EEA1 fusion, FGFR2-EIF4ENIF1 fusion, FGFR2-FILIP1 fusion, FGFR2-FOXP1 fusion, FGFR2-GAB2 fusion, FGFR2-GOPC fusion, FGFR2-INSC fusion, FGFR2-KCTD1 fusion, FGFR2-KIAA1217 fusion, FGFR2-KIAA1598 fusion, FGFR2-LAMC1 fusion, FGFR2-MACF1 fusion, FGFR2-MATR3 fusion, FGFR2-MCU fusion, FGFR2-MRVI1 fusion, FGFR2-NEDD4L fusion, FGFR2-NOL4 fusion, FGFR2-NRAP fusion, FGFR2-NRBF2 fusion, FGFR2-OPTN fusion, FGFR2-PAH fusion, FGFR2-PAWR fusion, FGFR2-POC1B fusion, FGFR2-PXN fusion, FGFR2-RABGAP1L fusion, FGFR2-RASSF4 fusion, FGFR2-RBM20 fusion, FGFR2-RPAP3 fusion, FGFR2-SFI1 fusion, FGFR2-SHROOM3 fusion, FGFR2-SLMAP fusion, FGFR2-SOGA1 fusion, FGFR2-SPICE1 fusion, FGFR2-STRN4 fusion, FGFR2-TACC1 fusion, FGFR2-TACC2 fusion, FGFR2-TFEC fusion, FGFR2-TRIM8 fusion, FGFR2-TTC28 fusion, FGFR2-TXLNB fusion, FGFR2-USH2A fusion, FGFR2-VCL fusion, FGFR2-WAC fusion, FGFR2-WDHD1 fusion, FGFR2-ZMYM4 fusion, FTFR2-TRIM8 fusion, Fusion, Fusion and E566A, Fusion and E566G, Fusion and K642I, Fusion and K642R, Fusion and K660M, Fusion and N549D (N550D), Fusion and N549K (N550K), Fusion and V563L, Fusion and V565I, Fusions, Oncogenic mutations, Oncogenic mutations and NOT Amplification, Oncogenic mutations and NOT V564, Exon 18 truncating mutations, Amplification, FGFR2-E1-17AND Amplification, Extracellular domain deletion, H167_N173del, S252W, C287R, W290C, I291_Y308del, K310R, Y375C, C382R, C382R (G380R), C383R, V395D, C492, K505E, M537I, N549D (N550D), N549F, N549H, N549H (N550H), N549K, N549K (N550K), N549S, N550, L552F, V563I, V563L, V564F, V564I, V564L, V564M, E565A, V565, V565I, V565L, E566A, E566G, K569M, L617M, L617V, L618F, L618M, L618V, K641N, K641R, K642I, K642R, L642R, N653S, K659M, K659N, K660M, K660N, R664W, Y674*, R678H, Y678*, L681fs*, P686*, S687fs*, S694*, FGFR2 C382R, FGFR2 I291_Y308del, FGFR2 W290C, FGFR2 Y375C, FGFR2 rearrangement, FGFR2-E18, FGFR2-E18-C2, FGFR2-E18-C3, FGFR2-E18-C4, FGFR2-I17, FGFR2-IIIb:Overexpression, FGFR2-USP33, FGFR2-delE18, FGFR2b:Overexpression, Overexpression, Rearrangements, Splice mutations, Truncating mutations
FGFR2

C382R (G380R)
FGFR3

FGFR1-TACC3:fusion, FGFR1-TACC3:fusion_V1, FGFR1-TACC3:fusion_V3, FGFR3 fusions, FGFR3-BAIAP2L1 fusion, FGFR3-TACC3 fusion, FGFR3-TACC3_V1 fusion, FGFR3-TACC3_V3 fusion, Fusion, Fusions, High mRNA expression and FGFR3-TACC3 fusion, High mRNA expression and Oncogenic mutation, Oncogenic mutations, Oncogenic mutations and NOT V565 and NOT V550, Amplification, R248C, S249C, G370C, G372C (G370C), S373C (S371C), Y373C, Y373C (Y375C), Y375C, Y375C (Y373C), F386L, A393E, V443, M528I, N540K, N540S, V553M, V555G, V555K, V555L, V555M, L608V, K650E, K650M, S764fs*6, High mRNA expression, High mRNA expression and G370C, High mRNA expression and R248C, High mRNA expression and S249C, High mRNA expression and Y373C, Overexpression
FGFR4

V550E, V550L
FH

Oncogenic mutations, Loss-of-function mutations (germline)
FLCN

Loss-of-function mutations
FLI1

EWSR1-FLI1 Fusion
FLT3

Oncogenic mutations, Amplification, F691L, D835, D835V, D835Y, I836, Y842C, Internal tandem duplication, Kinase domain mutation
FOLR1 (Folate receptor alpha)

Overexpression, Protein expression
FRS2

Amplification

G
GLI1

Overexpression
GLI2

Overexpression
GNA11

Oncogenic mutations, Q209L
GNAQ

Oncogenic mutations
GNAS

Oncogenic mutations, R201C, R201H
GPC3

Protein expression
Globo H

Expression

H
H3F3A

K27M, K28M, G34R, G34V
HGF

Amplification, Overexpression
HLA-A

A*03
HLA-A+PMEL

HLA-A:A*02:01 and PMEL:Protein expression
HLA-A2

A*02:01
HLA-A2+PRAME

HLA-A2:A*02:01 AND PRAME:Protein expression
HPV genotype

HPV16-positive
HRAS

Oncogenic mutation, Oncogenic mutations, G12C, G12D, G12S, G12V, G13D, G13R, G13V, Q61R, Q95H
Homologous Recombination Deficiency Score (HRD)

High
Human Papillomavirus Status

Negative

I
IDH1

Oncogenic mutation, Oncogenic mutations, R119P, G131A, R132, R132C, R132C+D279N, R132G, R132H, R132L, R132S, D279N, S280F, G289D, H315D
IDH2

Oncogenic mutation, Oncogenic mutations, R140, R140Q, R172, R172G, R172K, R172M, R172S, R172T, R172W, V305M
IL3RA

Overexpression
IRS2

Amplification, Protein expression
IRS2+BRAF

IRS2:Amplification AND BRAF:V600E
IRS2+KRAS

IRS2:Amplification AND KRAS:G13D
Immunoscore IC

High
Intrinsic subtype

Basal-like, HER2-enriched, Luminal A, Luminal B, Normal-like

J
JAK1

deletion, F958C, F958V, P960, Loss-of-function mutations
JAK2

PCM1-JAK2 fusion, deletion, V617F, Y931C, Y931C and V617F, Loss-of-function mutations

K
KAT6A

Amplification, Overexpression
KDM6A

Oncogenic mutations, Loss-of-function mutations
KEAP1

Oncogenic mutations
KEAP1+KRAS

KRAS:G12C AND NOT KEAP1:Oncogenic mutations
KIT (CD117)

NOT oncogenic mutations, Oncogenic mutations, Oncogenic mutations and NOT Amplification, Oncogenic mutations and NOT Amplification and NOT Exon 17 mutation, Exon 9 mutation, Exon 9 mutations, Exon 11 deletion, Exon 11 mutation, Exon 11 mutation and Exon 13 mutation, Exon 11 mutation and Exon 14 mutation, Exon 11 mutation and Exon 17 mutation, Exon 11 mutation and Exon 18 mutation, Exon 11 mutations, Exon 13 mutation, Exon 17 mutation, Exon 17 mutations, Amplification, Exon11 deletion, A502_Y503dup, A502_Y503dup and N822K, Y553N, D557, K558_G565delinsR, V559A, V559C, V559D, V559G, V560D, V560D and V654A, V560D and and V670I, V560G, V560_Y578del, V560del, L576P, P577_Y579del, K624E, Y627C, K642E, V654A, V654A and A829P, V654A and D816A, V654A and D820A, V654A and N822K, N655K, N655S, V669D, T670A, T670I, T670V, Y672C, D677N, N680K, F681L, R796G, C809G, D816, D816A, D816E, D816F, D816G, D816H, D816I, D816V, D816Y, I817L, D820A, D820E, D820G, D820N, D820V, D820Y, N822H, N822I, N822K, N822T, N822Y, Y823D, A829P, S840N, D842V, Overexpression, Protein expression
KLHL6

Protein expression
KMT2A

Rearrangement
KMT2C

deletion, Loss-of-function mutations
KRAS

KRAS:Oncogenic mutations + CDH1:Protein expression + VIM:NOT Protein expresssion, NOT KRAS:oncogenic mutation, NOT oncogenic mutations, Oncogenic mutation, Oncogenic mutation AND NOT G12C, Oncogenic mutations, Exon 3 insertion, Amplification, Amplification and NOT missense variant, G12C AND Amplification, V8L, V9F, A11_G12delinsGD, G12, G12A, G12C, G12D, G12F, G12R, G12S, G12V, G12W, G13C, G13D, G13V, V14I, V14L, K16T, L19F, Q22K, D33E, A59S, A59T, G60_A66dup, Q61E, Q61H, Q61K, Q61L, Q61P, Q61R, E62D, E62_A66dup, Y64N, R68S, M72L, G77V, H95D, H95N, H95Q, H95R, Y96C, Y96D, Y96H, Y96N, Q99K, Q99L, K117N, D119H, P121H, A146P, A146T, A146V, R149C, Switch 2 duplication
KRAS+ERBB3

KRAS:Oncogenic mutations and ERBB3:Overexpression
KRAS+MET

MET:exon 14 skipping mutation and KRAS:Oncogenic mutations
KRAS+Microsatellite Instability

KRAS:Oncogenic mutations AND Microsatellite Instability:High
KRAS+Mismatch repair

KRAS:Oncogenic mutations AND Mismatch repair:deficient
KRAS+NRAS

NOT KRAS:exon 2 mutation and NOT KRAS:exon 3 mutation and NOT KRAS:exon 4 mutation and NOT NRAS:exon 2 mutation and NOT NRAS:exon 3 mutation and NOT NRAS:exon 4 mutation
KRAS+NRAS+BRAF

NOT KRAS:Oncogenic mutation and NOT NRAS:Oncogenic mutation and NOT BRAF:Oncogenic mutation
KRAS+STK11

KRAS:G12C and STK11:Oncogenic mutations
KRAS+TP53

KRAS:Oncogenic mutations and NOT TP53:Alteration

L
LGALS1

Protein expression
LRP1B

Oncogenic mutations, Deletions, Loss-of-function mutations, Truncating mutations
LTK

CLIP1-LTK fusion, I565N, F568C, L590M, L592F, G596R, D597N, L650F, G663A
LZTR1

Loss-of-function mutations
Loss-of-heterozygosity score

High

M
MAP2K1

Oncogenic mutations, Negative regulatory domain deletion, F53L, Q56P, Q56_V60del, K57N, K57T, K57_G61del, L98_K104delinsQ, I99_K104del, E102_I103del, P105_107del, C121S, P124L, P124Q, P142L, E203K, K757E
MAP2K1+BRAF

MAP2K1:P124 and BRAF:V600
MAP2K2

Oncogenic mutations, V35M, L46F, Q60P, C125S, N126D, Y134H
MAP2K4

Oncogenic mutations
MAP3K1

Oncogenic mutations
MAP3K1+PIK3CA

MAP3K1:Oncogenic mutations AND PIK3CA:Oncogenic mutations
MAPK1 (ERK2)

Y36H, Y36N, P58L, P58S, P58T, Y64N, C65Y, Y131F, A189V, S202P, D321G, D321N, E322K
MAPK3 (ERK1)

Y53H, G54A, S74G, P75L, Y81C, C82Y, R84H, Q90R, Y148H, G186D, A206V, S219P
MCL1

Amplification
MDM2

Amplification, Overexpression
MDM2+TP53

MDM2:Amplification AND NOT TP53:Oncogenic mutations
MDM2+TP53+IDH1

MDM2:Amplification AND NOT TP53:Oncogenic mutations AND NOT IDH1:Oncogenic mutations
MET

CAV1-MET fusion, CD74-MET fusion, Fusions, PTPRZ-MET fusion, PTPRZ1-MET fusion, TFG-MET fusion, Oncogenic mutation, Oncogenic mutations, Exon 14 Deletion, Exon 14 skipping mutation, Exon 14 splicing mutation, Exon 16 mutation, Amplification, S244fs, N375S, Y1003 (Y1021), Y1003S (Y1021S), F1007fs (F1025fs), D1010 (D1028), Y1021H (Y1003H), D1028H (D1010H), D1028N (D1010N), V1092I, H1094Y, H1094Y (H1112Y), N1100S, H1106D, G1163, G1163 (G1181), G1163R (G1181R), R1170Q, L1195V, L1195V (L1213V), F1200I, F1200I (F1218I), D1228, D1228 (D1246), D1228A (D1246A), D1228H (D1246H), D1228H (D1246N), D1228N, D1228N (D1246N), Y1230 (Y1248), Y1230C (Y1248C), Y1230H, Y1230H (Y1248A), Y1230H (Y1248H), Y1230S (Y1248S), D1246 (D1228), D1246N (D1228N), Y1248 (Y1230), Y1248H (Y1230H), M1250T, K1262R (K1244R), A, Alteration, Alterations, C, C.2888-27_2888-2delinsC, G, No protein expression, Overexpression, Protein expression, T, c.2888-14_2888-4del, c.2888-17_2888-6del c.2888-18_2888-9del, c.2888-20_2888-11del, c.2888-5_2944del, c.2935_2939del, c.3028+1G>, c.3028+2T>, c.3028+3A>, c.3028G>, c.3280C>
MET+KRAS

MET:Amplification and KRAS:G12V
MET+TP53

MET:Exon 14 skipping mutation and TP53:Oncogenic mutations
MGMT

Loss of protein expression, Loss-of-function mutations, Low protein expression, Methylation, Promoter methylation, Unmethylated
MLH1

Loss of protein expression, Loss-of-function mutations
MRAS

Q71R
MRE11A

Oncogenic mutations (germline), L169Rfs*14, Loss-of-function mutations
MSH2

R359S (germline), Loss of protein expression, Loss-of-function mutations
MSH6

Loss-of-function mutations
MSLN

Overexpression, Protein expression
MTAP

deletion, Loss of protein expression
MTOR

Oncogenic mutations, L1460P, E2014K, F2108L, L2209V, Q2223K, E2419K, L2427Q
MTORC1

Oncogenic mutations
MUC1

Protein expression
MYB

MYB-NFIB fusion, Alteration, Overexpression
MYC

Oncogenic mutations, Amplification, Overexpression
MYCL

Amplification, Overexpression
MYCN

Oncogenic mutations, Amplification, Overexpression
MYD88

Oncogenic mutations, M232T, S243N, L265P, Gain-of-function mutations
Microsatellite Instability (MSI)

High, Stable
Microsatellite instability+Mismatch repair

NOT Microsatellite instability:high AND NOT Mismatch repair:deficient
Mismatch repair (MMR)

Deficient, High, NOT Deficient, Proficient
Molecular subtype

BLIA molecular subtype
Mutational signature

SBS3 signature

N
NBN

Oncogenic mutations
NECTIN4

Amplification, Protein expression
NF1

Oncogenic mutations, Oncogenic mutations (germline), deletion, N184fs, Q1336*, R2637*, Loss-of-function mutations
NF1+KIT

NF1:Oncogenic mutations AND NOT KIT:Oncogenic mutations
NF1+MET

NF1:Oncogenic mutation AND MET:Amplification, NF1:Deletion AND MET:Amplification
NF1+SUZ12

NF1:deletion AND SUZ12:deletion, NF1:Loss-of-function mutations AND SUZ12:Loss-of-function mutations
NF2

Oncogenic mutations, Oncogenic mutations (germline), deletion, Loss-of-function mutations, Truncating mutations
NOTCH1

Oncogenic mutations, R2327fs*, Alterations, Overexpression
NOTCH2

Gain-of-function mutations, Rearrangements
NOTCH3

Overexpression
NPM1

Oncogenic mutation
NRAS

Oncogenic mutation, Oncogenic mutations, Amplification, G12, G12C, G12D, G12S, G13, G13D, G13R, G13V, Q61, Q61H, Q61K, Q61L, Q61R, Q61S, L95H
NRG1

APP-NRG1 fusion, ATP1B1-NRG1 fusion, CD74-NRG1 fusion, CDH1-NRG1 fusion, CLU-NRG1 fusion, DOC4-NRG1 fusion, Fusion, Fusions, ITGB1-NRG1 fusion, POMK-NRG1 fusion, RBPMS-NRG1 fusion, SDC4-NRG1 fusion, SLC3A2-NRG1 fusion, VAMP2-NRG1 fusion, VTCN1-NRG1 fusion, High mRNA expression, Overexpression
NTRK1

ARHGEF2-NTRK2 fusion, ATP1A4-NTRK1 fusion, Alterations AND NOT fusion, BCAN-NTRK1 fusion, CD74-NTRK1 fusion, CDC42BPA-NTRK1 fusion, CGN-NTRK1 fusion, CGN-NTRK2 fusion, CTRC-NTRK1 fusion, DCTN1-NTRK1 fusion, DDR2-NTRK1 fusion, DIAPH1-NTRK1 fusion, EPS15-NTRK1 fusion, EPS15L1-NTRK1 fusion, ERC1-NTRK1 fusion, Fusion, Fusions, GON4L-NTRK1 fusion, IRF2BP2-NTRK1 fusion, IRF2BP2-NTRK2 fusion, KIF21B-NTRK2 fusion, KIRREL-NTRK2 fusion, LMNA-NTRK1 fusion, LMNA-NTRK2 fusion, MEF2D-NTRK2 fusion, NFASC-NTRK1 fusion, PDE4DIP-NTRK1 fusion, PDIA3-NTRK1 fusion, PDP0E4IP-NTRK2 fusion, PEAR1- NTRK1 fusion, PLEKHA6-NTRK1 fusion, PPL-NTRK1 fusion, SQSTM1-NTRK1 fusion, TMP3-NTRK1 fusion, TPM3-NTRK1 fusion, TPM3-NTRK2 fusion, TPR-NTRK1 fusion, TPR-NTRK2 fusion, TRIM33-NTRK1 fusion, TRIM63-NTRK1 fusion, Amplification, V573M, F589L, G595R, A608D, G667A, G667C, G667S, High mRNA expression
NTRK2

ABI2-NTRK2 fusion, AFAP1-NTRK2 fusion, AGAP1-NTRK2 fusion, ATP6V1A-NTRK2 fusion, Alterations AND NOT fusion, BEND5-NTRK2 fusion, C1orf112-NTRK2 fusion, CCDC88A-NTRK2 fusion, CHAMP1-NTRK2 fusion, CYP2E1-NTRK2 fusion, DENND5A-NTRK2 fusion, DNM3-NTRK2 fusion, ETV6-NTRK2 fusion, Fusion, Fusions, GKAP1-NTRK2 fusion, GNAI1-NTRK2 fusion, GNAQ-NTRK2 fusion, KANK1-NTRK2 fusion, KANK2-NTRK2 fusion, KCTD16-NTRK2 fusion, KCTD8-NTRK2 fusion, NACC2-NTRK2 fusion, PAPPA-NTRK2 fusion, PHF20L1-NTRK2 fusion, QKI-NTRK2 fusion, RBPMS-NTRK2 fusion, SBF2-NTRK2 fusion, SHANK1-NTRK2 fusion, SORBS1-NTRK2 fusion, SOS1-NTRK2 fusion, SPEC1L-NTRK2 fusion, SQSTM1-NTRK2 fusion, STMN1-NTRK2 fusion, STRN-NTRK2 fusion, TLE1-NTRK2 fusion, TRAF2-NTRK2 fusion, UGDH-NTRK2 fusion, VAMP4-NTRK2 fusion, Q596E, Q596P, G623S, F633L, G639R, V689M, G709C, High mRNA expression
NTRK3

AKAP13-NTRK3 fusion, ARNT2-NTRK3 fusion, Alterations AND NOT fusion, BCR-NTRK3 fusion, EGR3-NTRK3 fusion, EML4-NTRK3 fusion, ETV6-NTRK3 fusion, FAM19A2-NTRK3 fusion, FOXJ2-NTRK3 fusion, Fusion, Fusions, IQGAP1-NTRK3 fusion, KANK1-NTRK3 fusion, KIF7-NTRK3 fusion, MN1-NTRK3 fusion, MYO5A-NTRK3 fusion, RBPMS-NTRK3 fusion, SOX6-NTRK3 fusion, SPEC1L-NTRK3 fusion, SPECC1L-NTRK3 fusion, SQSTM1-NTRK3 fusion, TFG-NTRK3 fusion, TPM4-NTRK3 fusion, VIM-NTRK3 fusion, F617C, F617I, F617L, G623E, G623R, G696A, G696C, High mRNA expression, Protein expression
NUTM1

Protein expression

P
PALB2

Oncogenic mutations, Oncogenic mutations (germline), Loss-of-function mutations, Loss-of-function mutations (germline), Reversion mutations
PAXIP1

Oncogenic mutations
PBRM1

Oncogenic mutations, Loss of protein expression, Loss-of-function mutations, Truncating mutations
PDCD1LG2

Amplification
PDGFB

COL1A1-PDGFB Fusion
PDGFRA

FIP1L1-PDGFR fusion, FIP1L1-PDGFRA Fusion, FIP1L1-PDGFRA fusion and T674I, Fusion, Oncogenic mutations, Exon 12 mutation, Exon 14 mutation, Exon 18 deletion, Exon 18 mutation, Amplification, V516D, W559_R560del, R560del, V561D, P567P, N659K, T674I, D842V, D842V and T674R, D842V and V654A, D842Y, D842_H845del, D842_I843delinsIM, D842del, I843_D846del, I843_H846del, I843del, Overexpression, Protein expression
PDGFRB

Fusions
PGR

Protein expression
PIK3CA

Oncogenic mutation, Oncogenic mutations, Amplification, R88Q, G118D, N345K, N345T, C420R, E453K, E542, E542K, E542K and E453, E542K and E726K, E542K and M1043, E543Q and H1047R, E545, E545A, E545D, E545G, E545K, E545K and E453, E545K and E726, Q546, Q546E, Q546R, Q546X, E726, E726K and H1047R, M1043, M1043I, H1047, H1047L, H1047R, H1047R and E453, H1047R and E726K, H1047Y, G1049R, H1074R, Helical domain mutation, Kinase domain mutation, Kinase domain mutations
PIK3CA+ESR1 (ER)+ERBB2 (HER2)

PIK3CA:Oncogenic mutations and ESR1:protein expression and NOT ERBB2:amplification and NOT ERBB2:overexpression
PIK3CA+FGFR1

PIK3CA:Oncogenic mutation AND FGFR1:Alteration
PIK3CA+FGFR2

PIK3CA:Oncogenic mutation AND FGFR2:Alteration
PIK3R1

Oncogenic mutation, Oncogenic mutations, deletion, S361fs
PIK3R2

G373R
PMS2

K706Sfs, Loss-of-function mutations
POLD1

Oncogenic mutations, D402N, L606M, Loss of protein expression
POLE

Oncogenic mutations, P286R, S297F, S297Y, T323A, F367S, V411L, L424I, P436R, A456P, S459F
POU2F3

Protein expression
PPM1D

Loss-of-function mutations
PPP2R2A

Oncogenic mutations
PRKCA

Fusion
PRKCB

Fusion
PRKDC

Oncogenic mutations, Loss-of-function mutations
PSMA

Protein expression
PTCH1

Oncogenic mutations, Loss-of-function mutations, Truncating mutations
PTEN

Oncogenic mutations, Deletions, deletion, N48K, G209V, Alteration, Loss of protein expression, Loss-of-function mutations
PTEN+ERBB2 (HER2)

PTEN:Loss of protein expression and ERBB2:amplification
PTPN11

Oncogenic mutations, D61V, E72K, E76K, E76V, P491Q, Loss-of-function mutations

R
RAC1

P29S
RAD21

Oncogenic mutations
RAD50

Oncogenic mutation, Oncogenic mutations, Deletions, Loss-of-function mutations
RAD51

Loss of protein expression, Low protein expression
RAD51B

Oncogenic mutations
RAD51C

Oncogenic mutations, Oncogenic mutations (germline), Loss of promoter methylation, Loss-of-function mutations, Low protein expression, No protein expression, Promoter methylation
RAD51D

Oncogenic mutations
RAD54L

Oncogenic mutations
RAF1

ANO10-RAF1 fusion, ATG7-RAF1 fusion, FYCO1-RAF1 fusion, Fusion, Fusions, GATM-RAF1 fusion, GOLGA4-RAF1 fusion, NFIA-RAF1 fusion, QKI-RAF1 fusion, RAF1-CCDC176 fusion, RAF1-TRAK1 fusion, SRGAP3-RAF1 fusion, Oncogenic mutations, K106N, S257P, P261L, P261T, G356E, G361A, S427T, D447N, M469I, E478K, R554K
RASA1

Oncogenic mutations, Loss-of-function mutations
RB1

Oncogenic mutation, Oncogenic mutations, Heterozygous deletion, deletion, Copy number loss, Loss of protein expression, Loss-of-function mutation, Loss-of-function mutations
RBM10

Loss-of-function mutations
RET

ARHGAP12-RET fusion, CCDC186-RET fusion, CCDC6-REF fusion, CCDC6-RET fusion, CCDC88C-RET fusion, CLIP1-RET fusion, DOCK1-RET fusion, ERC1-RET fusion, Fusion, Fusions, KIAA1468-RET fusion, KIAA1549L-RET fusion, KIF13A-RET fusion, KIF5B-RET fusion, KTN1-RET fusion, NCOA4-RET fusion, PRKAR1A-RET fusion, RBPMS-RET fusion, RELCH-RET fusion, RET fusions and NOT KIF5B-RET fusion, RUFY3-RET fusion, TRIM24-RET fusion, TRIM33-RET fusion, Oncogenic mutations, Oncogenic mutations (germline), Oncogenic mutations and NOT Amplification, Exon 10 deletion, D378_G385delinsE, V591_607del, C609, C611, C618, C620, C630, D631_L633delinsE, D631_L633delinsV, E632_L633del, C634, T636_V637insCRT, K666N, V738A, I788N, L790F, G801S, V804L, V804M, Y806C, Y806N, G810A, G810C, G810R, G810S, A883F, D898_E901del, D903_S904delinsEP, S904F, M918T, Cysteine rich domain mutation, Rearrangement
RICTOR

Amplification
RIF1

Oncogenic mutations
RIT1

P128L
RNF43

Oncogenic mutations, deletion, R371fs, G659fs, P660fs, C-terminal truncating mutations, Frameshift mutations, Loss-of-function mutations, Truncating mutations
ROS1

CD74-ROS1 fusion, CD83-ROS1 fusion, CEP85L-ROS1 fusion, EZR-ROS1 fusion, Fusion, Fusions, GOPC-ROS1 Fusion, KLHDC2-ROS1 fusion. SLC34A2-ROS1 fusion, LRIG1-ROS1 fusion, MYH9-ROS1 fusion, SDC4-ROS1 fusion, SLC12A2-ROS1 fusion, SLC34A2-ROS1 fusion, SLC4A4-ROS1 fusion, TPM3-ROS1 fusion, TPR-ROS1 fusion, Amplification, E1395G, L1947R, L1951R, G1971E, S1986F, S1986Y, F2004C, L2026M, G2032R, D2033N, S2060G, F2075V, V2098U, G2101A, D2113G, L2155S
ROS1+MET

ROS1:fusion AND MET:D1228N
RSPO1

Fusion

S
SDHA

Oncogenic mutation, Oncogenic mutations (germline)
SDHB

Oncogenic mutation, Oncogenic mutations (germline)
SDHC

Oncogenic mutation
SDHD

Oncogenic mutation
SETD2

Oncogenic mutations, Truncating mutations
SEZ6

Protein expression
SF3B1

Oncogenic mutations, R625C, R625H, R625L, H662Q, K700E
SLAMF7

Protein expression
SLC1A5

Overexpression
SLC39A6

Protein expression
SLX4

Loss-of-function mutations
SMARCA2

Loss-of-function mutations
SMARCA2+SMARCA4

SMARCA2:Loss of protein expression and SMARCA4:Loss of protein expression
SMARCA4

Oncogenic mutations, Loss of protein expression, Loss-of-function mutations
SMARCB1

Oncogenic mutations, deletion, Loss of protein expression
SMC3

Oncogenic mutations
SMO

Oncogenic mutations, R168H, E181K, R199Q, N219D, L221P, N223D, L225R, T241M, V281C, W281L, V321M, A327P, T336I, T349I, T349P, L353F, D384N, V386A, S387N, D388N, C390R, S391N, V404M, I408V, L412F, V414A, G453D, G457S, A459V, D473, D473G, D473H, D473Y, N476K, D477G, Q477E, E481G, G497W, D506N, P513L, E518, E518K, K519R, E522K, T534I, W535L, T548I, K564E, T640A, P641A, P698T, P739L, P739S
SPEN

Oncogenic mutations
SRSF2

Oncogenic mutations, P95H
SS18

SS18-SSX fusion
SSTR2

Protein expression
STAG2

Oncogenic mutations
STEAP1

Protein expression
STK11

Oncogenic mutations
STK11+KRAS

STK11:Oncogenic mutations AND KRAS:Oncogenic mutations
SUFU

Loss-of-function mutations
SUZ12

Loss-of-function mutations

T
TACSTD2 (Trop2)

T256R, Overexpression, Protein expression
TNFRSF17

Protein expression
TNFRSF8 (CD30)

Protein expression
TOP1

E418K, L721R
TP53

NOT oncogenic mutations, Oncogenic mutation, Oncogenic mutations, P151S, Y163C, R175H, L194R, Y220C, R248Q, R248W, R273C, R273H, R273L, R282W, Alteration, Overexpression
TP53+KRAS

TP53:Oncogenic mutations AND KRAS:G12, TP53:Oncogenic mutations AND KRAS:G13
TP53+RB1

TP53:Oncogenic mutations AND RB1:Deletion, TP53:Oncogenic mutations AND RB1:Oncogenic mutations
TP53BP1

Oncogenic mutations
TP63

Amplification
TSC1

Oncogenic mutations, Oncogenic mutations (germline)
TSC2

Oncogenic mutations, Oncogenic mutations (germline), Q1178*, Loss-of-function mutations
Tumour Mutational Burden (TMB)

High
Tumour Mutational Burden+Microsatellite

Tumour Mutational Burden:High and Microsatellite:Stable
Tumour Mutational Burden+Microsatellite Instability

Tumour Mutational Burden:High and NOT Microsatellite instability:high
Tumour Mutational Burden+Mismatch repair

Tumour Mutational Burden:High and Mismatch repair:Proficient, Tumour Mutational Burden:High and NOT Mismatch repair:deficient
Tumour microenvironment

Immunomodulatory subtype, Inflamed immune phenotype

U
U2AF1

S34F, Q157R

V
VCTN1 (B7-H4)

Protein expression
VHL

Oncogenic mutations, Oncogenic mutations (germline)

W
WT1

EWSR1-WT1 fusion, Loss-of-function mutations
WWTR1

Fusion, WWTR1-CAMTA1 fusion (TAZ-CAMTA1 fusion)

X
XPO1

C528S
XRCC2

Loss-of-function mutations

Y
YAP1

Fusion, YAP1-TFE3 fusion